School of Brain Cells & Circuits "Camillo Golgi"

Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy)

Programme 2015

Modeling the brain: from neurons to integrated systems

Course Directors: Egidio D’Angelo, Claudia Gandini Wheeler-Kingshott, Michele Migliore

The 2015 Course of the school of brain cells and circuits was dedicated to brain modeling and theory. Bottom-up models, descending from cellular and molecular biophysics, and top-down models, derived from neuropsychology and non-invasive brain measurements (mostly brain imaging using MRI), are both needed to integrate the micro-, meso and macro-scale of brain organization and to pilot future experimentation. Brain theories need to interface with new experimental measurements and cellular circuit models simulations. This approach requires merging expertise and knowledge deriving from different disciplines, from Physics and Mathematics to Biology, Psychology and Medicine. The 2015 Course gathered scientists providing an integrated view of this enormous field with the aim of teaching the foundations of brain modeling and theory.

Sunday 29-11-2015
Arrival and opening reception

Monday 30-11-2015  

Biophysically detailed models of neurons and networks



Egidio D’Angelo, Claudia Gandini Wheeler-Kingshott, Michele Migliore


Erik DeSchutter (OIST, Okinawa, Japan)
“Stochastic effects in neurons at molecular and cellular levels”

Egidio D’Angelo (University of Pavia, Pavia, Italy)
“Complex dynamics in single neuron and microcircuit models”

Eilif Muller (EPFL, Lausanne, Switzerland)
“Reconstruction and simulation of cortical microcircuitry”


Practice – interactive demonstration
Michael Hines (YALE, USA) – Modeling in Python-NEURON

General discussion

Tuesday 1-12-2015  

Large-scale models and theory



Michele Migliore (CNR, Palermo, Italy)
“Odor perception through network self-organization: large-scale modeling of the olfactory bulb”

Michael Hines (YALE, USA)
“Parallel Network Modeling with NEURON”

Alain Destehxe (CNRS, France)
“Realistic mean-field models of neuronal populations”

Fabrizio Gabbiani (Baylor College, Huston, USA)
“Biophysics and Neural Computations Underlying Visually-Guided Collision Avoidance Behaviors”


Practice – interactive demonstration
Alessandra Pedrocchi & Alberto Antonietti (Milano, Italy) – Closed-loop robotic control using spiking neural networks

General discussion

Wednesday 2-12-2015  

Models of brain systems: the connectome



Claudia Gandini Wheeler-Kingshott (UCL, UK)
“The need for brain connectomic and the role of structural and functional MRI”

Shyam Diwakar (Amrita, India)
“From Network Models to Applications and Vice-versa: Cerebellum Network Models and their Abstractions”

Demian Battaglia (Aix Marseille Université, FR)
“From structural to functional connectivity networks, via emergent dynamics”

Martjin van der Heuvel (University Medical Center, Utrecht, Holland)
“Micro and macro network analysis of the connectome”

Eugene Duff (Oxford University, UK)
“Functional network modelling using fMRI”


Practice – interactive demonstration 
Demian Battaglia (Aix Marseille, France) & Eugene Duff (Oxford, UK) – Software for brain modeling & connectomics

General discussion and closure of the meeting

Thursday 3-12-2015  



Centro Fermi

HBP Education Programme

Fondazione Istituto Neurologico Nazionale C. Mondino


Università di Pavia


Siemens Healthcare S.r.l.

Collegio Borromeo, Pavia (Italy)
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